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Studies suggest that viral communities can interact with gut bacteria, potentially exacerbating inflammation or influencing immune cell behavior ( 5 The interaction mechanism between gut microbiota and ferroptosis in IBD The gut microbiota regulates ferroptosis-related signaling pathways through multiple mechanisms, including (i) remodeling luminal iron availability and epithelial iron handling, (ii) rewiring host antioxidant capacity and lipid peroxidation tone via microbial metabolites, and (iii) modulating mucosal immune programs that determine the ferroptosis threshold of distinct cell types

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10.1093/ibd/izab277 79 WangQ.OuY.HuG.WenC.YueS.ChenC.et al (2020)