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243 While SRT1720 has demonstrated hepatoprotective effects in various metabolic disease models, potential toxicity at higher doses poses challenges for clinical translation

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337 The MSU crystals are initially engulfed by macrophages, which then facilitate the assembly and activation of the NLRP3 inflammasome, preceded by priming through pathways that activate NF-B, such as those initiated by the engagement of Toll-like receptors (TLRs) within the TLR family