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Literature was searched in PubMed and Web of Science up to March 31, 2026, using combinations of terms including GLP-1 receptor agonist, semaglutide, liraglutide, tirzepatide, obesity, taste, flavour, dysgeusia, food preference, dietary intake, eating behaviour, appetite, satiety, food reward, craving, liking, wanting, and interoception. Studies were considered relevant if they addressed gustatory sensory function, hedonic food evaluation, food preference, dietary intake, cue-related food motivation, interoceptive modulation, or reward-related neural processing

N Engl J Med 2025;393:1796-1806 [9] Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial, December 2025: Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial | Eli Lilly and Company [10] Fourth High-level Meeting of the UN General Assembly on the prevention and control of NCDs and the promotion of mental health and wellbeing (HLM4), September 2025: [11] Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study, November 2025: Thousands of patients from Scotlands poorest areas to benefit from landmark UK government-funded obesity study - GOV.UK [12] Non-Traditional Channels: The Compounded GLP-1 Market

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After 52 weeks, participants who took 36 milligrams of orforglipron saw a key blood sugar marker reduce by nearly 2 percent, while those who received 14 milligrams of oral semaglutide saw levels drop by nearly 1.5 percent

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