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The main reason is that the large amount of extracellular matrix deposition in the ovarian cancer microenvironment leads to tumor vascular collapse, reduced vascular perfusion, poor drug delivery and blocked migration of cytotoxic T cells to the tumor area (139)

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doi:10.1097/01.aids.0000131354.14408.fb [DOI] [PubMed] [Google Scholar] 54.Scarpini E, Sacilotto G, Baron P, Cusini M, Scarlato G

(2010) Methods in mammalian autophagy research, Cell , 140 , 313-326, doi: 10.1016/j.cell.2010.01.028

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