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Febuxostat, a novel selective XOR inhibitor, exhibits superior efficacy to non-pharmacological interventions in asymptomatic hyperuricemia trials, particularly in ameliorating arterial stiffness assessed using cardio-ankle vascular index (CAVI) (Sun et al., 2025)

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rather, it underscores the necessity for more robust, high-quality, and standardized evidence to substantiate their routine application in clinical practice