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The balance between adaptive and apoptotic unfolded protein responses regulates beta-cell death under ER stress conditions through XBP1, CHOP and JNK
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With regard to its bioactivity and function, the contribution to normal blood clotting and to the maintenance of normal bones were authorized as health claims in the European Union [95]
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Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications
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