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When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

Pharmaceuticals, 16 (11), Article 1615

Vitamin B12 is a vitamin and is essential for your central nervous system, red blood cells, DNA and metabolism

The patients in whom we have observed less meaningful response tend to be those who have not addressed the foundation, who have unrealistic expectations, or who have other factors (significant sleep restriction, untreated metabolic comorbidities, chaotic eating patterns) that any pharmacological adjunct would struggle against

Note: We have no affiliation with Gary Brecka - this article is based on publicly shared information.

Zhang et al., 2011)