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Their widespread adoption (a market size over $40 Billion USD in 2024 1 Markets, R

Furin-mediated priming of viral S protein at S1/S2 (P R RA R 685 ) [the underlined AAs refer to critical residues needed for the furin recognition] is a key determinant in the pathogenesis of COVID-19 55,73,329

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Optimization-focused researchers consistently cite receptor selectivity not effect magnitude as the primary compound selection criterion: the research question determines the receptor profile needed, not the other way around

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