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Washington University and SK Biosciences took a similar approach, genetically fusing SARS-CoV-2 RBD on the exterior surface of the two-component protein nanoparticle I53-50, which is a computationally designed 120-subunit complex with icosahedral symmetry constructed from trimeric (I53-50A) and pentameric (I53-50B) components

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While it is generally well-tolerated, long-term surveillance continues to monitor for potential risks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Coleman M., Blass J.P