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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

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Moreover, daily B12 supplementation has improved the clinical outcome of hospitalized patients with COVID-19 55 and was also effective in alleviating long COVID symptoms from a patient recovered from mild COVID-19 56

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