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An important feature of dysbiosis is the reduction of butyrate-producing taxa such as Faecalibacterium prausnitzii and Roseburia spp

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Untreated, BH4 deficiency with high phenylalanine can lead to developmental delays, muscle dysfunction, cognitive impairment, and sometimes epilepsy.[ref] Rare mutations in different genes in the BH4 pathway can cause different genetic conditions

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