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The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60

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Mechanisms of BPC 157 Cytoprotection in Stress-Induced Gastric Ulceration

Semax increases BDNF expression in targeted regions relevant to mood, including the hippocampus and prefrontal cortex, the very areas where BDNF deficits are most pronounced in depressed individuals