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Recently, the Food and Drug Administration (FDA) approved the use of some GLP-1 agonists for promoting weight loss in people with obesity

Balwani M, Balistreri W, DAntiga L, Evans J, Ros E, Abel F, Wilson DP

In this context, murine studies have shown that sweet taste receptors (TAS1R2 and TAS1R3) are predominantly expressed in the hypothalamus and brainstem, whereas bitter receptors (TAS2R116, TAS2R118, TAS2R138, TAS2R104) are mainly expressed in the arcuate nucleus, ventromedial hypothalamus, dorsomedial hypothalamus, and nucleus of the solitary tract (120, 121)

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When lacking or depletion of GSH, it may cause producing toxic effects or increasing the toxic effects of many chemicals or environmental factors

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