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Poly(ADP-ribose) Polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages

Activation of Gq signaling promotes insulin secretion mainly through 2 pathways: the DAG/PKC pathway and the IP 3 /Ca 2+ pathway (46, 47)

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Somatostatin binds to somatostatin receptors on somatotrophs, which couple to Gi proteins that inhibit adenylyl cyclase, reduce cAMP levels, and suppress both GH synthesis and release - directly opposing Sermorelin's stimulatory effects