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To accommodate GLP-2 rather than GLP-1, GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices (TMs) 1, 5, 7 and extracellular loop 1 (ECL1)

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What neither position disputes is the core finding that makes today's hearing clinically significant: across all four compounds on Day 1's agenda, there are no large, controlled, randomized human trials establishing safety or efficacy for the proposed injectable routes

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