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Contact your GP or prescriber if you experience: Persistent or severe palpitations that don't settle within a few minutes Dizziness or lightheadedness that occurs frequently or interferes with daily activities Fainting episodes or near-fainting (pre-syncope) Chest pain or discomfort, particularly if associated with exertion Unusual shortness of breath or difficulty breathing Persistent rapid heartbeat at rest (above 100 beats per minute) Symptoms that worsen progressively rather than improving after dose stabilisation Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe chest pain or pressure, especially if radiating to the arm, jaw, or back Sudden severe shortness of breath Loss of consciousness or fainting Severe, persistent abdominal pain (which could indicate pancreatitis) Signs of severe dehydration (dark urine, inability to keep fluids down, confusion) For non-emergency but urgent concerns, NHS 111 can provide guidance on appropriate next steps