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Namun sebaliknya, meningkatnya kadar radikal bebas akan memicu timbulnya stres oksidatif

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Polycycl Aromat Comp 24:697712 Hellou J, Beach DG, Erskine S, Marklevitz SA, Saunders L (2010) Balanced fates of pyrene and 1-hydroxypyrene in snails, Ilyanassa obsoleta , exposed to spiked sediments

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Although TFBUT was the primary clinical endpoint, the study was powered on TNF- as a biologically relevant surrogate due to limited prior ophthalmic data for GSH-C4