The difference is how much liquid you need to draw to reach your target dose
Pre-Blend Vials (15 mg: 12.5 mg reta + 2.5 mg cag) One vial covers about 6-10 weekly doses depending on where you are in titration
The short answer is yes, you can
10.1016/j.bbadis.2023.166984 Biochim Biophys Acta Mol Basis Dis
Also, most mechanistic, epigenetic, endocrine, and microbiome studies to date have been conducted in high-income settings, while studies from LMICs are more observational or epidemiologic, limiting the generalizability of findings
Power calculations suggest that previous studies would have had limited power to detect an effect size similar to that identified in our study (Supplementary Table 23), and also differed in terms of drug type, disease cohort and analytical choices