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GHRP-2 (pralmorelin) is slightly more potent on GH (~16 baseline), less orexigenic, but maintains a dose-dependent increase in cortisol (+20-40%) and prolactin (+15-30%)

1 Heres what the 40-week results showed: HbA1c reductions: Tirzepatide 5 mg: reduced HbA1c by 2.01 percentage points Tirzepatide 10 mg: reduced HbA1c by 2.24 percentage points Tirzepatide 15 mg: reduced HbA1c by 2.30 percentage points Weight loss: Tirzepatide 5 mg: 7.6 kg (8.5% of body weight) Tirzepatide 10 mg: 9.3 kg (approximately 10% of body weight) Tirzepatide 15 mg: 11.2 kg (13.1% of body weight) Achieving target HbA1c: 92% of participants on 15 mg achieved HbA1c below 7% 51% achieved HbA1c below 5.7% (normal, non-diabetic range) These results were significantly better than semaglutide 1 mg (the comparison drug in the trial), where 81% achieved HbA1c below 7% and participants lost an average of 6.2 kg

07.02.25 July report showed MDL growth The total number of pending actions in the MDL grew to 1,997

It works by blocking the pigment from reaching the top layer of the skin

Not all of these factors are equally modifiable, but awareness of them supports a more targeted provider conversation about next steps

References Bray GAPJ