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A comprehensive immunogenicity assessment must evaluate peptide sequence foreignness, endosomal TLR signaling, linker stability, and synthetic impurity profiles as interconnected risk factors rather than as isolated considerations

Approximately 20% of the US gastroenterologists and primary care providers most of the time or always recommend antidepressants for IBS-D and IBS-C 9

The oxidation of PDI by Ero1 is thought to occur through disulphide exchange that results in the formation of reduced Ero1 (Gross et al , 2004)

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