There is no clinical evidence that tapering provides any benefit before switching
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220 However, the total depletion of NAD + could be very toxic to noncancerous cells, thereby it has been considered to rescue them using NAPRT precursor, nicotinic acid
And with type 2 diabetes on the rise and more people turning to GLP-1s for their weight loss benefits, this trend isnt just continuing
In practice, most clinicians would likely taper tirzepatide down before initiating retatrutide to manage overlapping GI side effects and assess the new compound's individual response