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3 The DPP-4 enzyme is also found in other tissues, including those from the liver, kidneys, pancreatic duct, and lymphocytes

2015 Jan;7(1):31-8

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3 If initial therapy with metformin and lifestyle efforts are not adequate to achieve individualized glycemic targets, the guidelines recommend that patients should progress to dual therapy by adding either another oral agent, basal insulin, or an injectable GLP-1 receptor agonist

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase