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Subcutaneous liraglutide 3 mg (once daily) and semaglutide 2.4 mg (once weekly) have been approved for obesity management and a higher dose of subcutaneous semaglutide (7.2 mg once weekly) is currently assessed in a phase 3 trial (Table 1)

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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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