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Show details ABSTRACT Understanding the involvement of the insulin-GH-IGF-axis in the different phases of human growth, development, and metabolism is the key to understanding human pathophysiology

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Epigenetic regulation plays a pivotal role in the pathogenesis of DKD, providing a molecular basis for the phenomenon of metabolic memorywhereby transient episodes of hyperglycemia induce long-lasting pathological changes in renal cells (64, 65)

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