Protozoa: Trichomonas vaginalis (Trichomoniasis) Giardia lamblia (Giardiasis) Entamoeba histolytica (Amoebiasis) Pharmacokinetics Absorption: Well absorbed orally Distribution: Widely distributed (including CNS, liver, and abscesses) Metabolism: In the liver Excretion: Mainly via urine (may darken urine) Indications / Uses Anaerobic bacterial infections Brain abscess Pelvic infections Intra-abdominal infections Aspiration pneumonia Bacterial vaginosis Protozoal infections Amoebic dysentery Giardiasis Trichomoniasis Helicobacter pylori therapy (as part of triple or quadruple therapy) Pseudomembranous colitis caused by Clostridioides difficile (alternative to vancomycin) Dosage (Adults typical) Anaerobic infections: 400500 mg every 8 hours for 710 days Amoebiasis: 500750 mg every 8 hours for 710 days Giardiasis: 250 mg every 8 hours for 57 days Trichomoniasis: 2 g single dose (or 400 mg every 8 hours for 7 days) (Dosage may vary based on infection type and patient factors.) Adverse Effects Gastrointestinal: Nausea, metallic taste, dry mouth, vomiting, diarrhea Neurological: Headache, dizziness, peripheral neuropathy (with prolonged use) Other: Dark or reddish-brown urine (harmless) Furry tongue or oral thrush Hypersensitivity reactions (rare) Contraindications Hypersensitivity to metronidazole First trimester of pregnancy (use with caution) Breastfeeding (may need temporary discontinuation) Drug Interactions Alcohol: Causes disulfiram-like reaction (nausea, vomiting, flushing) Warfarin: Potentiates anticoagulant effect (increased bleeding risk) Phenytoin / Phenobarbital: Reduce metronidazole levels Precautions Avoid alcohol during treatment and for 48 hours after completion Use with caution in hepatic impairment Monitor for neurological symptoms with long-term therapy Key Point Metronidazole is highly effective against anaerobic and protozoal infections, but never mix it with alcohol due to the severe disulfiram-like reaction
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You may notice your appetite returning
It can also help to avoid greasy or very spicy foods, especially when you are just starting treatment
Glutamine functions through multiple mechanisms within your cellular processes
Our laboratory has previously investigated the analgesic efficacy of the DPP-4 inhibitor teneligliptin in an animal model of neuropathic pain involving the partial transection of the sciatic nerve [18]
