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In-vitro studies suggest GHK-Cu may stimulate collagen synthesis and growth factor signaling in skin fibroblasts

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However, a number of studies have recently shown that WNT signaling is also critical for the initiation of differentiation 2 , as well as the maintenance of the DE marker sex determining region y-box 17 (SOX17) 10 , and indeed our recent publication has proven that activation of the WNT pathway alone can efficiently differentiate hPSCs to DE 11

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