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This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]

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However, practical considerations exist, including Wegovy's effects on appetite, gastric emptying, and hydration status, which may influence how your body responds to creatine supplementation

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