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Mechanism of Action The precise biological mechanism of DSIP continues to be investigated, but researchers have proposed several pathways that may explain its activity in laboratory models

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In addition, ATGL depletion significantly downregulated HSL and MGL levels in brown adipose tissue (BAT), while the total lipase activity in WAT was barely affected [53]

This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells

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