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Metabolic Regulation: Restoration of SCFA production, particularly butyrate, activates G-protein-coupled receptors (GPR41/43), inhibits the NF-B signaling pathway, and reduces the release of pro-inflammatory cytokines such as IL-6 and TNF- (Siddiqui and Cresci, 2021

For example, certain FTO variants associate with greater baseline appetite dysregulation, potentially contextualizing why some individuals benefit from GLP-1 earlier in their metabolic journey

Diabetologia 60, 15661576

D., Baack, B

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An overview of autophagy: morphology, mechanism, and regulation