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It may influence the gut-brain axis, HPA (hypothalamic-pituitary-adrenal) axis, and broader hormonal loops involved in energy balance and stress response

Not only can they have effects on the efficacy of these neurosurgical interventions but may also influence the eligibility of patients with cognitive impairment for these procedures, though future research is needed to study these effects in the context of neurosurgery

Rao Y et al