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C201S/C408S), penetrating the positively charged wall around C408 (Fig

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in the inactive state, two TM5 residues (Val319 and Phe315) formed an additional cholesterol pocket with TM4, presenting the highest average residence time (186 ns) across all sites, while, in the active state, the cholesterol pocket was located closer to the bottom of TM3 and TM4, involving Leu260 in ECL2

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