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Differential diagnosis: Cholangiofibrosismarked pericholangial fibrosis with proliferation of biliary epithelium and metaplastic changes of glandular epithelium (e.g., goblet cells, Paneth cells)

This approach aims to prevent further harm and explore suitable therapeutic alternatives.According to Dr Saptarshi Bhattacharya, senior consultant of endocrinology at Apollo Hospitals, while the study raises significant concerns, it's essential to interpret the findings cautiously

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Consoli A, Formoso G, Baldassarre MPA, et al

Depending on the agent, the mechanism of action is related to their anticholinergic and calcium channel blocking properties leading to smooth muscle relaxation in the gut (Table 1 gives an overview of the most-described randomized controlled trials (RCTs) assessing the effect of different antispasmodics in approximately 2900 IBS patients