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Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels

Bottom line If you are comparing Wegovy, Ozempic, Zepbound, Saxenda, Victoza, and Trulicity, the biggest takeaway is simple: the best medication depends entirely on the clinical goal

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We (41), and others (42), have shown that the GLP-1R plays an important role in the control of beta cell mitochondrial function, a key process for optimal insulin secretion (43), with our recent interactome results unveiling direct interactions between GLP-1R and cholesterol biosynthesis and metabolism factors located at ER-mitochondria membrane contact sites (41)