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GLP-1 drugs are synthetic versions of glucagon-like peptide-1 - a hormone your body already makes to regulate blood sugar and appetite

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What actually causes an anal fissure Most acute fissures start with mechanical trauma passing a hard, large stool, chronic diarrhea, or straining

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This extension is derived from a portion of a porcine growth hormone sequence and adds additional mass and structural context at the amino end of the chain