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Best Pract Res Clin Rheumatol 36(3):101773 Bang JS, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS (2009) Anti-inflammatory and anti-arthritic effects of piperine in human interleukin 1-stimulated fibroblast-like synoviocytes and in rat arthritis models

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This might have counteracted any potential benefit from TGF- pathway inhibition 2