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One major advantage of intramuscular injection is that its increasingly effective at raising blood levels of B12

Cell Tissue Res 377 (2), 153159

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First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne

This not only contributes to pain relief but can also improve mood and cognitive function