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However, appetite suppression can increase the risk of falling, age-related muscle and bone density loss, hypoglycemia misdiagnosis, and nutrient deficiencies

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Similarly, the LEADER trial with liraglutide showed a 13% reduction in MACE in patients with type 2 diabetes and high cardiovascular risk

Effect of oral semaglutide compared with placebo and subcutaneous semaglutide on glycemic control in patients with type 2 diabetes: a Randomized Clinical Trial

The Jorge study specifically found cardiovascular and kidney benefits in this population, which is encouraging

The paradoxical thing about the evidence so far: the published animal data on Epitalon have predominantly shown no increased cancer incidence, some even report a reduced tumour rate (Anisimov et al., 2003)