Medical Writing Assistance The authors thank Manthan Mehta, Kumardeep Paul, Syed Rahman, Mansij Biswas, Arpit Jain, Jignesh Ved, from Boehringer Ingelheim (India) medical affairs for providing writing assistance for this manuscript in accordance with Good Publication Practice (GPP3) guidelines ( Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published
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However, using other peptidic ([Leu 5 ]- and [Met 5 ]-enkephalins and UFP-512 ([H-Dmt-Tic-NH-CH(CH 2 -COOH)-Bid])) and non-peptidic (SNC-80 ((+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethyl-benzamide) and ARM-390) ligands we didn't confirm such assumption but our data rather suggest that DOR selective agonists promote profound desensitization compared to non-selective ligands (Marie et al., 2003a
Ans : Typically between 4 to 12 weeks, depending on your body, dosage, and form used
