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Garlic and SAC were recently shown to inhibit activation of NF-B in different cell types, including endothelial cells, so they can be likely to inhibit atherosclerosis and hypertension by suppressing the expression of NF-B and lowering ROS concentration

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10.1016/j.anl.2014.08.014 8 BatandierC.LeverveX.FontaineE

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Meanwhile, L-carnitine enhanced mitochondrial -oxidation activities and the expression of carnitine palmitoyltransferase 1 mRNA significantly, whereas it depressed the mRNA expression of adipogenesis-related genes

Bariatric surgery remains the gold standard for severe obesity (BMI 40 or 35 with complications)