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It describes a timeline where symptoms peak three to six weeks after starting or increasing treatment, stabilize through weeks six to twelve, then gradually improve as metabolic adaptation completes

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Patients prescribed weight loss medications often have multiple cardiovascular and metabolic risk factors that independently increase NAION risk, including diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea

By suppressing appetite to control obesity, GLP-1 receptors may also blunt pleasure responses, leading to emotional dullness