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rapid dose increases often worsen symptoms Discuss with your clinician about temporarily slowing dose escalation, reducing dose or potential gap if symptoms are intolerable When to seek medical advice Contact your healthcare provider immediately if you experience: Inability to keep any fluids down for more than 24 hours Signs of dehydration (extreme thirst, dark urine, dizziness) Vomiting blood or material that resembles coffee grounds Severe or persistent abdominal pain Fever accompanying vomiting Symptoms that severely impact your quality of life despite management strategies Long-term outlook For most GLP-1 patients, nausea and vomiting are temporary side effects that become more manageable as their bodies adjust to the medication