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The data in c and e represent the results of three independent experiments

Less sunlight exposure = less melatonin = more oxidative stress

Baseline hypertension or tachycardia are contraindications

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Notwithstanding all of these experimental findings, to date there is not sufficient clinical evidence to justify the use of NRF-2 in medical practice

Specifically, it states: "The strictest interpretation of the trial would suggest that all small breed dogs with a left apical systolic murmur of grade 3/6 or louder should have radiographs taken and an echocardiogram performed to determine if substantial cardiac enlargement is present and pimobendan therapy warranted." * In a July 2017 "update", the CEG changed the "above 11.5" to "11.5 or above", making the risk even greater that dogs with no enlargement at all will be prescribed pimobendan