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This supported the notion that the observed phenotype in SLC30A1 -KO cells was mediated by effects related to intracellular accumulation of zinc, such as the up-regulation of metallothioneins

Once delivered into cells, glutathione participates in recycling antioxidants, supporting detox enzyme pathways, and maintaining redox balance

10.1021/pr070492f 81 VargoM

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Results Anti-nitrative effect of trisulfides as an introductory part of the study Given the potent anti-oxidative functions of GSSSG and LASSS, the first set of experiments was designed to examine if these trisulfides have potential to prevent peroxynitrite-induced nitration-dysfunction of HGF by ECL-Western blotting (see Figure 1a for the in vitro experimental design)