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Discussion Recent publications of positive CV outcome trials with SGLT2i (empagliflozin and canagliflozin) and GLP1 RA (liraglutide and semaglutide) and the positive effects of treatment with these drugs utilizing the pathophysiological defects of T2D have caused a paradigm shift in the way the disease is treated [1,2,3,4]

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Even when there is no obvious pigmentation, oral mucosal melanocytes are always present and produce some melanin but the amount produced is determined by their melanogenic activity [14]

Hu et al., 2025

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