GLP-1RA Lipid-Specific Outcomes While the GLP-1RAs used for weight loss, semaglutide and tirzepatide, have garnered much focus, multiple other GLP-1RA medications have shown positive outcomes on lipid profiles: dulaglutide has shown reduction in total cholesterol and LDL-C [65], liraglutide has shown reduction in LDL-C and ApoCIII [66], and exenatide has shown reduction in LDL-C and total cholesterol and increase in HDL-C [67]
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Most studies were brief and used dosages within the upper consumption limits, even though no significant adverse effects were documented in the supplementation trials that were part of this analysis