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In particular, abnormalities in glutamatergic and GABAergic neurotransmission across key brain regions such as the hippocampus, amygdala, and cerebellum may underlie several characteristic clinical features of ASD, including impairments in learning and memory, atypical visual perception (e.g., hypersensitivity to bright light), repetitive behaviors, and avoidance across social settings (157, 158)

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Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function

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Some lyophilization processes create denser powder requiring 5-10 minutes hydration before complete dissolution