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The human microbiome, especially the gut microbiota, comprises numerous symbiotic bacterial species (e.g., Lactobacillus , Bacillus , Clostridium , Enterococcus , and Ruminococcus ) that collectively represent approximately 90% of the gut flora (Rinninella et al., 2019

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Because NCX mito is involved in insulin secretion from -cells [53], one can speculate that hyperuricemia can affect -cell function via this pathway

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Therefore, some researchers recommend direct measurement in target tissues or the collection of multiple blood samples at different time points to account for the detoxification effect on circulating levels [66]