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Coincidental timing is perhaps the most common explanation

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5.2 Microbial factors directly modulating -cells: LPS, indoles and BefA SCFAs, particularly butyrate, protect -cells not only by enhancing GLP-1 secretion but also through profound immunomodulatory effects that attenuate islet inflammation

Antioxidants may decrease melanogenesis by blocking free-radical formation or by scavenging free radicals already formed

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