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Glutathione supplementation does not alter tirzepatide pharmacokinetics, but NAC in high doses (above 1800mg daily) can affect cysteine-dependent metabolic pathways that influence insulin sensitivity, which may interact with tirzepatide's glucose-lowering effects in patients with type 2 diabetes

Behavioral deficits were measured using stereotyped climbing, open field, forced swimming, and Y-maze tests, followed by sacrifice

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Rare cases of joint symptoms have been reported, so new pain should be evaluated promptly