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Based on serial transgenic mouse models, it has been confirmed that IRF7, IRF8, and IRF9 were anti-hypertrophy factors that are consistently down-regulated in cardiac hypertrophy and heart failure

In lupus-prone mice, HSP70-based DNA vaccines have shown promise in suppressing anti-dsDNA antibody production, reducing proinflammatory responses, promoting tolerogenic immune responses, and prolonging survival (153)

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[DOI] [PubMed] [Google Scholar] 26.Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP